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MIK665 CAS No.: 1799631-75-6

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    2023-08-30 20:07

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Chemical Structure: MIK665

CAS No.: 1799631-75-6

 

MIK665(MIK 665, S 64315, S64315)

Catalog No.: URK-V595  Only Used For Lab.

MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities.

 

Biological Activity

MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities.
MIK665 (S-64315) binds to and inhibits the activity of Mcl-1, which promotes apoptosis of cells overexpressing Mcl-1.
Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.

 

Physicochemical Properties

M.Wt

875.413

Formula

C47H44ClFN6O6S

CAS No.

1799631-75-6

Storage

Solide Powder

-20 °C 3years;

4°C 2years

In Solvent

-80°C 6 Months

-20°C 1 Months

Solubility

10 mM in DMSO

Chemical Name

(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid

 

References

1. Cassier PA, et al. Br J Cancer. 2017 Oct 10;117(8):1089-1098.

URK-V595_COA
URK-V595_SDS
URK-V595_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use

 

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